Canagliflozin CAS NO.842133-18-0

The first branch was founded in 2010,called Anqing World Chemical Co.,Ltd.Mainly responsible for the development of domestic and international business.In 2015,Haikang established the second branch,called Anqing Xuanyu Medical&Technology Co., Ltd, it is an R&D company that selects reliable technology and cooperative research partner for our corporation.

Haikang is committed to R&D,manufacture and sales of chemical raw materials API and intermediates.Meanwhile,we also provide services like product customization,process improvement,achievement transfer, etc. Through years effort,Haikang has made remarkable achievements in the R&D and production of anti-virus,antidiabetic,antineoplastic,beauty and whitening resist oxidation series API and intermediates.The main products are Ganciclovir, Sitagliptin, Vildagliptin, Silodosin and Imatinib API and Intermediates.

To deal with increasingly competition,Haikang adheres to “Customer is First,Technology is Leading,Quality is Life,Honesty for Developing”,and optimizes actively the products and better service to customers.

Canagliflozin is a new drug in class of sodium-glucose cotransporter 2 inhibitors used for treatment of type 2 diabetes mellitus. We describe a patient who developed moderately severe acute pancreatitis as an untoward consequence after being initiated on this drug. To the best of our knowledge, this is the first reported case of canagliflozin-associated acute pancreatitis in clinical literature.

Repaglinide is a white or almost white crystalline powder; it is odorless. It is easily soluble in chloroform, slightly soluble in ethanol or acetone, and almost insoluble in water; slightly soluble in 0.1mol/L hydrochloric acid solution.

Specific rotation Take this product, accurately weigh it, add ethanol to dissolve it and dilute it quantitatively to make a solution containing about 20mg per 1ml, measured according to law (General Rule 0621), the specific rotation is +7.6° to +9.2°.

The absorption coefficient is taken from this product, accurately weighed, dissolved in 0.1mol/L hydrochloric acid solution and quantitatively diluted to make a solution containing about 20μg per 1ml, according to ultraviolet-visible spectrophotometry (General Rule 0401), measured at a wavelength of 243nm Absorbance, absorption coefficient is 221～235.