Ganciclovir sodium CAS NO.107910-75-8

Anqing World Chemical Co.,Ltd.Mainly responsible for the development of domestic and international business.In 2015,Haikang established the second branch,called Anqing Xuanyu Medical&Technology Co., Ltd, it is an R&D company that selects reliable technology and cooperative research partner for our corporation.

Haikang is committed to R&D,manufacture and sales of chemical raw materials API and intermediates.Meanwhile,we also provide services like product customization,process improvement,achievement transfer, etc. Through years effort,Haikang has made remarkable achievements in the R&D and production of anti-virus,antidiabetic,antineoplastic,beauty and whitening resist oxidation series API and intermediates.The main products are Ganciclovir, Sitagliptin, Vildagliptin, Silodosin and Imatinib API and Intermediates.

To deal with increasingly competition,Haikang adheres to “Customer is First,Technology is Leading,Quality is Life,Honesty for Developing”,and optimizes actively the products and better service to customers.

1. Immune deficiencies include cytomegalovirus retinitis that occurs in AIDS patients.
2. Prevent cytomegalovirus infections that may occur in recipients of organ transplants.

Ganciclovir sodium is an analog of 2'-deoxyguanine nucleotide, which can inhibit the replication of herpes virus. The mechanism of action is that ganciclovir is first phosphorylated into monophosphate by the protein kinase homologue encoded by CMV (UL97 gene), and then further phosphorylated into diphosphate and triphosphate by cellular kinases. In CMV-infected cells, the level of triphosphate is 100 times higher than that in non-infected cells, suggesting that this product can be preferentially phosphorylated by Chemicalbook in infected cells. Once ganciclovir forms triphosphates, it can persist for several days in CMV-infected cells. The triphosphate of ganciclovir is thought to inhibit viral DNA synthesis by: 1) competitively inhibiting viral DNA polymerase; 2) co-entering into viral DNA, leading to the termination of viral DNA elongation. It has been clinically confirmed that this product is effective against infections caused by cytomegalovirus (CMV) and herpes simplex virus (HSV).

Ganciclovir is a commonly used purine antiviral drug developed and marketed after acyclovir. Its structure is similar to that of acyclovir, but its antiviral effect is stronger than that of acyclovir, and its chemical properties are more stable than Chemicalbook. It was first invented by Verheyden et al. At present, its raw materials and preparations are on the market in China. Ganciclovir is an antiviral drug, which has a strong antiviral effect both in vivo and in vitro.